Lecture
- PRERECORDED - Minimal Residual Disease Detection by Flow Cytometry: Clinical Relevance
- at -
- ICM Saal 4a
- Type: Lecture
Lecture description
This lecture highlights the role of flow cytometry in the detection of minimal residual disease (MRD), using multiple myeloma as a prototypical example. Over recent years, flow cytometry has become a cornerstone of diagnostic evaluation and longitudinal disease monitoring in plasma cell disorders.
It illustrates how multiparameter flow cytometry supports initial diagnosis through the identification of aberrant plasma cell populations and the definition of disease-specific immunophenotypic profiles, and demonstrates how these profiles are subsequently applied in therapy monitoring and MRD assessment, enabling sensitive detection of residual malignant cells beyond conventional response criteria.
It illustrates how multiparameter flow cytometry supports initial diagnosis through the identification of aberrant plasma cell populations and the definition of disease-specific immunophenotypic profiles, and demonstrates how these profiles are subsequently applied in therapy monitoring and MRD assessment, enabling sensitive detection of residual malignant cells beyond conventional response criteria.
