As manufacturing systems grow more complex, traditional machine-level virtualization is no longer enough. This session explores how system twins—advanced digital replicas of entire production systems—are unlocking new levels of efficiency, agility, and innovation. By simulating workflows, predicting performance, and enabling virtual commissioning, system twins empower manufacturers to optimize operations before physical systems are ever powered on. Attendees will learn how system-level virtualization drives predictive maintenance, reduces downtime, enhances collaboration, and improves training through immersive VR/AR environments with real-world examples. Accelerate design cycles, maximize floor space and achieve sustainability goals.