Lecture
Supercritical fluid chromatography as a sustainable analytical method
- at -
- ICM Saal 5
- Type: Lecture
Lecture description
Supercritical fluid chromatography (SFC) is an old separation method and a long-time favourite for preparative purposes, where it’s advantages over normal-phase liquid chromatography (NPLC) have long been recognized, namely: GRAS (generally recognized as safe) mobile phase solvents, solvent economy and energy economy.
At the analytical scale, SFC has been more recently accepted, thanks to the introduction of improved instruments and facilitated hyphenation to mass spectrometry in the years 2010s’. Technological evolutions have therefore opened a wide range of applications, outside the traditional pharmaceutical analysis, including natural products, plastic materials or environmental analysis. While the solvent economy is less obvious in an analytical system than in a preparative system, the greenness of analytical SFC may still show up in different aspects of the method, including column durability, or consumables economy with online sample preparation methods. Further reduction of column dimensions would however require additional improvements in the instrument design.
In this presentation, the main characteristics of SFC will be explained and examples will be provided to illustrate its green features.
At the analytical scale, SFC has been more recently accepted, thanks to the introduction of improved instruments and facilitated hyphenation to mass spectrometry in the years 2010s’. Technological evolutions have therefore opened a wide range of applications, outside the traditional pharmaceutical analysis, including natural products, plastic materials or environmental analysis. While the solvent economy is less obvious in an analytical system than in a preparative system, the greenness of analytical SFC may still show up in different aspects of the method, including column durability, or consumables economy with online sample preparation methods. Further reduction of column dimensions would however require additional improvements in the instrument design.
In this presentation, the main characteristics of SFC will be explained and examples will be provided to illustrate its green features.
