Lecture
Sensors and Wearables for Next-Generation Healthcare
- at -
- ICM Saal 4b
- Type: Lecture
Lecture description
Disposable sensors are affordable and easy-to-use sensing devices for short-term or singleshot measurements. Over the last decade, they have become increasingly important for various applications, including from environmental, forensic, pharmaceutical, agricultural, and food monitoring to diagnostics, especially the point-of-care testing and wearables. In this talk, a broad spectrum of different biosensing approaches for next-generation on-site
testing will be presented: (i) Multiplexed on-site therapeutic drug monitoring of antibiotics from invasive and non-invasive samples toward personalized antibiotherapy[1], [2], (ii) CRISPR-powered electrochemical biosensors for nucleic-acid-amplification-free, simultaneous and on-site detection of multiple RNAs and other biomolecules for the management of infectious diseases[3], (iii) wearable microfluidic immunosensing devices for lab-on-a-bird applications and beyond, (iv) low-cost electrochemical paper-based wearable sensors that can be integrated to any type of facemask for wearable and continuous monitoring of breath biochemistry and/or testing of the infectious diseases such as coronaviruses from exhaled breath[4], and (v) light-controlled dynamic bioassays using optogenetic switches (OptoAssays) for wash- and pump-free point-of-care diagnostics[5].
Literature:
[1] H. C. Ates et al., “Biosensor-Enabled Multiplexed On-Site Therapeutic Drug Monitoring of Antibiotics,” Adv. Mater., p. 2104555, Sep. 2021, doi: 10.1002/adma.202104555.
[2] H.C. Ates et al., “Unraveling the impact of therapeutic drug monitoring via machine learning for patients with sepsis,” Cell Reports Med., p. 101681, Aug. 2024, doi: 10.1016/j.xcrm.2024.101681.
[3] M. Johnston et al., “Multiplexed biosensor for point-of-care COVID-19 monitoring: CRISPR-powered unamplified RNA diagnostics and protein-based therapeutic drug management,” Mater. Today, vol. 61, pp. 129–138, Dec. 2022, doi: 10.1016/j.mattod.2022.11.001.
[4] D. Maier et al., “Toward Continuous Monitoring of Breath Biochemistry: A Paper-Based Wearable Sensor for Real-Time Hydrogen Peroxide Measurement in Simulated Breath,” ACS Sensors, vol. 4, no. 11, pp. 2945–2951, Nov. 2019, doi: 10.1021/acssensors.9b01403.
[5] N. Urban, M. Hörner, W. Weber, and C. Dincer, “OptoAssay – Light-controlled Dynamic Bioassay Using Optogenetic Switches,” Sci. Adv., vol. 10, no. September, p. eadp0911, 2024, doi: 10.1126/sciadv.adp0911.
testing will be presented: (i) Multiplexed on-site therapeutic drug monitoring of antibiotics from invasive and non-invasive samples toward personalized antibiotherapy[1], [2], (ii) CRISPR-powered electrochemical biosensors for nucleic-acid-amplification-free, simultaneous and on-site detection of multiple RNAs and other biomolecules for the management of infectious diseases[3], (iii) wearable microfluidic immunosensing devices for lab-on-a-bird applications and beyond, (iv) low-cost electrochemical paper-based wearable sensors that can be integrated to any type of facemask for wearable and continuous monitoring of breath biochemistry and/or testing of the infectious diseases such as coronaviruses from exhaled breath[4], and (v) light-controlled dynamic bioassays using optogenetic switches (OptoAssays) for wash- and pump-free point-of-care diagnostics[5].
Literature:
[1] H. C. Ates et al., “Biosensor-Enabled Multiplexed On-Site Therapeutic Drug Monitoring of Antibiotics,” Adv. Mater., p. 2104555, Sep. 2021, doi: 10.1002/adma.202104555.
[2] H.C. Ates et al., “Unraveling the impact of therapeutic drug monitoring via machine learning for patients with sepsis,” Cell Reports Med., p. 101681, Aug. 2024, doi: 10.1016/j.xcrm.2024.101681.
[3] M. Johnston et al., “Multiplexed biosensor for point-of-care COVID-19 monitoring: CRISPR-powered unamplified RNA diagnostics and protein-based therapeutic drug management,” Mater. Today, vol. 61, pp. 129–138, Dec. 2022, doi: 10.1016/j.mattod.2022.11.001.
[4] D. Maier et al., “Toward Continuous Monitoring of Breath Biochemistry: A Paper-Based Wearable Sensor for Real-Time Hydrogen Peroxide Measurement in Simulated Breath,” ACS Sensors, vol. 4, no. 11, pp. 2945–2951, Nov. 2019, doi: 10.1021/acssensors.9b01403.
[5] N. Urban, M. Hörner, W. Weber, and C. Dincer, “OptoAssay – Light-controlled Dynamic Bioassay Using Optogenetic Switches,” Sci. Adv., vol. 10, no. September, p. eadp0911, 2024, doi: 10.1126/sciadv.adp0911.
