Lecture
Immune signatures of pulmonary Herpes-Simplex-Virus-1 reactivation in tracheal secretions of intensive care patients
- at -
- ICM Saal 4a
- Type: Lecture
Lecture description
Kevin Dennehy, Hellen Buijze, Eva Löll, Lukas Page, Lukas Schuierer, Sibylle Lang, Phillip Löhr, Monika Lorenz, Symon Karpynec, Philipp Simon, Reinhard Hoffmann
Herpes-Simplex-Virus-1 reactivates in the lungs of approximately 30% of intubated and mechanically ventilated intensive care patients, and may be clinically inapparent
or associated with severe ventilator-associated pneumonia. Reliable diagnosis of HSV-associated pneumonia remains an unsolved problem.
We hypothesized that immune signatures in tracheal secretions, which are routinely aspirated for diagnostic PCR, could be used to assess clinical status of intensive care patients.
We show that flow cytometric-based characterization of pulmonary immune responses in tracheal secretions may be used to distinguish between clinically insignificant HSV reactivation and development of HSV-associated pneumonia.
Herpes-Simplex-Virus-1 reactivates in the lungs of approximately 30% of intubated and mechanically ventilated intensive care patients, and may be clinically inapparent
or associated with severe ventilator-associated pneumonia. Reliable diagnosis of HSV-associated pneumonia remains an unsolved problem.
We hypothesized that immune signatures in tracheal secretions, which are routinely aspirated for diagnostic PCR, could be used to assess clinical status of intensive care patients.
We show that flow cytometric-based characterization of pulmonary immune responses in tracheal secretions may be used to distinguish between clinically insignificant HSV reactivation and development of HSV-associated pneumonia.
