Lecture
Exploring new possibilites for DESI-MS and its place within the ambient mass spectrometry landscape.
- at -
- ICM Saal 4b
- Type: Lecture
Lecture description
Desorption electrospray ionization mass spectrometry (DESI-MS) has established itself as a powerful ambient ionization technique since its introduction two decades ago, with MS imaging applications being the most reported in literature. However, the technique's potential extends far beyond spatially-resolved analysis. DESI-MS allows almost instantaneous chemical readouts from a whole range of sample types and when coupled with novel probe design, mass spectrometry analysis can be freed from the necessity to be within the immediate vicinity of the instrument itself.
Here we explore new analytical possibilities for ambient MS, where the constraints on the sample type, size and shape are loosened even further. A remote DESI probe, that can be used hand-held, is shown to provide chemical information down a three-metre umbilical back to the mass spectrometer. The performance and characteristics of this configuration will be described, as will the range of applications that may benefit from such a device. The fields of forensics, food-fraud, environmental and agriculture and healthcare may all find utility of such a flexible means of mass spectrometry analysis.
However, advances in the conventional implementation of DESI have not slowed down and examples of health care screening and single cell metabolomic profiling from cell culture populations will be presented as new applications that have been recently enabled. It is also
important to recognise that DESI is only one of many ambient MS techniques and we will examine how these capabilities complement rather than compete with established ambient MS techniques and discuss where DESI analysis offers unique advantages in the analytical
workflow.
Here we explore new analytical possibilities for ambient MS, where the constraints on the sample type, size and shape are loosened even further. A remote DESI probe, that can be used hand-held, is shown to provide chemical information down a three-metre umbilical back to the mass spectrometer. The performance and characteristics of this configuration will be described, as will the range of applications that may benefit from such a device. The fields of forensics, food-fraud, environmental and agriculture and healthcare may all find utility of such a flexible means of mass spectrometry analysis.
However, advances in the conventional implementation of DESI have not slowed down and examples of health care screening and single cell metabolomic profiling from cell culture populations will be presented as new applications that have been recently enabled. It is also
important to recognise that DESI is only one of many ambient MS techniques and we will examine how these capabilities complement rather than compete with established ambient MS techniques and discuss where DESI analysis offers unique advantages in the analytical
workflow.
